Have you thought about trying CBD for your dog’s pain, seizures, or anxiety? Here’s everything you need to know about CBD for dogs. Can Dog CBD interact with other medications that they're taking? Will it have a negative impact or create a great combo for our dog's health? What Happens When CBD Inhibits The Cytochrome P450 System? Using CBD Safely With Other Medication Side Effects Of CBD What Research Says Frequently Asked Questions Concerning CBD and Drug Interactions Discussing CBD And Drug Interactions With Your Vet List Of Known Drugs CBD Interacts With Next to CBD and the benefits
CBD for Dogs: Everything You Need to Know
In certain states, medical marijuana is an option for people seeking relief from ailments like seizures, pain, anxiety, and cancer.
Pet parents and veterinarians alike are naturally wondering whether cbd for dogs, in the form of products such as cbd oil for dogs or cbd dog treats, can provide the same benefits.
Here’s everything you need to know about CBD for dogs.
THC vs. CBD for Dogs
CBD is one of over 80 different chemical compounds called “cannabinoids” that have been derived from the cannabis (marijuana) plant. Unlike tetrahydrocannabinol (THC), perhaps the most famous cannabinoid, CBD is not psychoactive.
Instead, CBD shares important metabolic pathways with a class of drugs called NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen and Rimadyl. These pathways control many processes in the body, from inflammatory responses to blood clotting.
Do not give dogs straight marijuana or any product containing tetrahydrocannabinol (THC), the primary psychoactive component of marijuana. There is simply not enough research to justify the use.
CBD-based products, however, may help improve your dog’s quality of life when used in conjunction with other therapies.
Why Use CBD for Dogs?
CBD is often mentioned as a useful therapy for a variety of conditions, including pain management, arthritis, anxiety, seizures, and even cancer. Although the use of CBD in treating each of these conditions is under-researched, there are varying levels of scientific evidence for each scenario.
Because CBD shares metabolic pathways with anti-inflammatory drugs, it makes sense that it would help with certain inflammatory conditions (anything that ends with -itis is an inflammatory condition).
Osteoarthritis, often abbreviated as arthritis, is one of the most common inflammatory conditions in dogs.
One in four dogs will be diagnosed with arthritis in their lifetime, and by some estimates, as many as 60% of dogs exhibit some degree of the disease.
Research has shown that CBD can provide substantial pain relief in dogs with arthritis when given twice daily at appropriate doses.
In theory, the anti-inflammatory benefit seen in arthritic dogs could also be seen in dogs with other types of inflammatory pain, especially back pain from intervertebral disc disease (IVDD).
Preliminary studies in people have shown that combo products containing both CBD and THC are more beneficial for pain relief than when either drug is given alone. But no such research has been done on dogs, so THC should not be given to them.
Seizures are probably the most-studied application of CBD in people, but limited research exists for pets. In dogs, seizures can be caused by a vast number of underlying conditions.
With regards to idiopathic epilepsy specifically, there is some research that suggests that CBD could be useful in reducing seizure frequency in these dogs. However, these benefits are only seen with dogs that are given traditional anti-seizure medications at the same time.
Like seizures, the term “cancer” is an umbrella term that refers to an extremely diverse set of specific diseases, each with their own set of beneficial treatments.
In people, CBD has been studied for possible use in cancer patients, both to treat the tumor(s) directly, as well as to treat the secondary symptoms of cancer and chemotherapy. Very limited research has been done on the use of CBD for dogs with cancer.
However, the anti-nausea effects of CBD seen in people who undergo chemotherapy have also been documented in rats and ferrets, suggesting that dogs receiving chemotherapy may benefit from CBD treatment.
Perhaps the biggest misconception is that CBD is useful in managing a dog’s anxiety. In theory, it is possible that CBD, by reducing pain and inflammation, could indirectly reduce anxiety caused by pain or inflammation.
But because CBD is not psychoactive, it is unlikely that CBD has the ability to directly treat canine anxiety in the way that Prozac and other medications do. The use of CBD for anxiety in dogs, as with most conditions, requires substantially more research.
Potential Risks of CBD for Dogs
Overall, CBD itself seems to be incredibly safe in dogs and cats. However, numerous scientific papers have found that when given at the recommended doses, CBD does cause an elevation in an important liver value on bloodwork called alkaline phosphatase (ALP).
We are not yet sure whether the elevation of this liver value has any medical significance. It could signify that CBD causes irritation or damage to the liver. Alternatively, it could be an artificial finding in which the drug interferes with the way the lab measures the liver value.
Anecdotal reports do exist of dogs becoming somewhat sleepy or sedate if they receive extremely large doses of CBD, but those effects appear to resolve on their own with time.
CBD doesn’t appear to have any drug interactions when it’s given to a dog that’s on an anti-inflammatory drug like Rimadyl.
Because there is a theoretical risk of drug interaction, as with any medication, you should consult your veterinarian first before treating your dog with CBD.
THC Dangers for Dogs
Unlike CBD, THC ingestion can cause serious problems for your pet.
“The most significant [issue] is THC toxicity, meaning, essentially, they are high,” says Dr. Gary Richter, owner and medical director of Montclair Veterinary Hospital in Oakland, California. “Depending on how significantly a pet has been overdosed, the effects of that can be quite long-lasting, even days.”
During these episodes, a pet may not be able to stand or eat. If you suspect THC toxicity, take your pet to the veterinarian immediately. Secondary effects of THC, especially respiratory depression, should be monitored closely to avoid complications.
Overall, life-threatening risks for dogs from cannabis are “exceedingly rare,” Dr. Richter says. There is no documented lethal dose for THC in dogs. In fact, a dose of THC 1,000 times greater than the dose needed for a dog to feel “high” is still not lethal.
THC toxicity more often occurs when a pet has eaten a product that also contains chocolate, coffee, or raisins. “Even if the THC toxicity is not excessive, they can sometimes have problems due to these other ingredients,” says Dr. Richter.
How Much CBD Can You Give Dogs?
Though there are some topical treatments, CBD oil is typically administered orally to dogs, and giving the correct dosage is imperative. “As is the case with any medication, success has everything to do with dosing,” Dr. Richter says.
Studies on using CBD for dogs with arthritis or seizures generally use a dose between 2-8 mg/kg, with most papers erring on the lower side of that estimate (roughly 1-2 milligrams per pound of body weight), twice daily.
This dosage has been found to be both safe and somewhat effective for just the conditions studied (arthritis and seizures). Additional research is needed to evaluate the necessary dosages for CBD in treating other conditions.
One complication in attempting to properly dose dogs with CBD is that the US Food and Drug Administration (FDA) has found that many CBD products actually contain little, if any, CBD.
The only FDA-approved cannabinoid product, Epidiolex, could theoretically be prescribed by a veterinarian for epilepsy in dogs, although this would likely be cost-prohibitive. Because it is FDA-approved, though, the CBD content of this product would be accurate, unlike most other CBD products on the market.
Can Veterinarians Prescribe CBD for Dogs?
U.S. veterinarians are forbidden from prescribing/dispensing CBD, and cannot encourage or instruct clients to purchase CBD products.
However, they are free to talk to you about the potential risks and benefits of a treatment plan you may have devised on your own. If you are considering giving CBD to your dog, speak to your vet, and you may want to also speak with a veterinarian who has experience with CBD.
CBD for Dogs And Its Interaction With Other Medication
Dog CBD interaction is a reaction between CBD and the other drug your dog is taking. These days, more and more people are now including CBD in their dog’s everyday life.
However, is CBD oil interacting with other medications okay? Below, we’ll tackle if dog CBD can have a negative side effect on dogs taking other medication.
The benefits of CBD are great and are a safe supplement in general. However, will it complement other medications? Well, it depends on the drug they are taking.
Dog CBD Interaction with Medications
CBD and Rimadyl interaction for dogs
Rimadyl is a Non-Steroidal Anti-Inflammatory Drug or NSAID. NSAIDs are a class of drugs prescribed to manage pain or reduce inflammation in dogs.
Studies have shown that it doesn’t have any drug interaction with CBD. But that doesn’t mean it will not exist in the future.
In this case, dog CBD interaction will depend on the dog’s body chemistry and the dosage of CBD or Rimadyl. CBD can help maintain the dog’s well-being and balance with proper dosage.
CBD and Melatonin Interaction for Dogs
What even is Melatonin? Melatonin is a hormone released by the pineal gland in the brain that helps regulate the dog’s sleep and even waking up.
The powerful combination of CBD and Melatonin helps the dog’s wellness support. Some of the benefits found in CBD and Melatonin provide the same effects for your dogs.
CBD is known for its calming properties. Melatonin, on the other hand, provides comfort and restful sleep. This combo can work together to help maintain the dog’s well-being and proper rest.
CBD and Benadryl for Dogs
Benadryl is an antihistamine that is given to dogs that experience allergy symptoms.
It is usually prescribed by vets to treat environmental allergies or allergies caused by insect bites or stings.
It works by blocking the histamine (H-1) activity that causes allergic symptoms on a dog’s body. There is no known interaction between Benadryl and CBD.
But there can still be risks. CBD and Benadryl are both metabolized through the cytochrome P450 Enzyme System. This can increase the chances of doubling the side effects of both CBD and Benadryl.
It can potentially cause severe drowsiness or fatigue. We suggest checking with your vet before combining these two.
CBD And Glucosamine Interactions
CBD and Glucosamine can be an excellent combination for a dog that suffers from joint problems like arthritis or joint pain in general.
Glucosamine is one of the most popular over-the-counter arthritis medicines. It is usually given to manage pain on the joints caused by hip dysplasia. Glucosamine can also help with the treatment of spinal disc injury.
With the two-punch combo of CBD and Glucosamine, it can help reduce pain and inflammation from your dog’s joints.
CBD and Prednisone for Dogs
Dog CBD interaction with Prednisone is not recommended for dogs. Prednisone is a prescription steroid used to reduce inflammations, treat allergy symptoms, arthritis, and more.
CBD and Prednisone together are not recommended for dogs as they can increase the side effects of both. They are both inhibitors of the CYP450 Enzyme System.
If you’re planning to give CBD oil to your dogs while they are on different medications, it is best to consult with your vet in these situations.
CBD and Meloxicam Lethal Combo for Dogs
Meloxicam, likewise Rimadyl, is a Non-Steroidal Anti-Inflammatory Drug or NSAID. Meloxicam is prescribed as a pain killer that helps ease inflammation in dogs.
There is a chance that taking NSAIDs with CBD can increase the effects of these pain killers. It all comes down to proper dosage on meds and supplements.
You, as the owner, have the responsibility to research, talk to your vet, and monitor your dogs when taking the CBD route in addition to meloxicam.
Commonly Asked Questions
Will Benadryl help with Dog Anxiety?
Well, yes and no. You have to identify what kind or cause of their anxiety.
Benadryl can help reduce dog anxiety symptoms. It is also used as a sedative to help dogs during fireworks, thunderstorms, or traveling. But overall, Benadryl is not helpful for dogs struggling with anxiety or phobias.
It has high efficiency in helping dogs with motion sickness. However, it can have opposite side effects on rare occasions where your dogs will be hyperactive rather than sedated.
Proper Dosage of Benadryl for Dogs
Giving dogs about 2-4mg of Benadryl for every kilogram of body weight is good. However, it is still best to consult with your vet and wait for their approval before you take action.
Administering the correct dosage of Benadryl for dog anxiety is crucial. The wrong amount can have serious consequences.
How often do I give CBD oil to my dog?
This all depends on the dog’s condition. Some dogs can benefit from daily doses, and others can not.
For example, dogs suffering from arthritis or seizures can benefit from a daily or twice a day dose of CBD between 2-8mg/kg or lower. An interval of eight to twelve hours is advised when CBD twice a day.
A good rule of thumb when administering CBD oil for your dog is 1-5mg CBD for every 10 pounds of their body weight.
What happens if your dog takes too much CBD?
CBD is a non-toxic and non-psychoactive compound meaning it will not get ‘high’. However, when taken too much intense, concentrated CBD, potential side effects can develop.
A few of these symptoms are lethargy (lack of energy), vomiting, drowsiness, urinary incontinence, and hypersensitivity.
Dog CBD Interaction with other Medication Summary
Due to a lack of research, there are still many things that we don’t yet know about the world of CBD, not just for humans but also for dogs. But we cannot deny the great benefits of CBD for dogs.
When giving CBD to our dogs, there are still many things to consider. We must focus not only on the correct dosage but also on other medications that they need.
Studies showed that CBD has no known interaction with medications, but it doesn’t mean it will stay like that. Dog CBD interaction will depend on the dog, CBD, and the medicine.
Our vets usually prescribe these medicines. It is still the best choice to consult with your vet in CBD drug interactions.
Since the FDA doesn’t regulate CBD products yet, most US Veterinary and Pharmacy boards are advised to avoid prescribing or discussing CBD until further notice.
Always remember that you are the one in control when it comes to CBD oil drug interactions.
You have the power to help your dogs maintain a well-balanced life. Research, consult with your vet, and monitor.
CBD Drug Interactions: Which Medications Should You Avoid
Next to CBD and the benefits that can help treat a long list of medical disorders, the other thing that has driven its popularity is its low risk for causing side effects. In fact, research shows CBD can be so safely used that it has the potential to replace other drugs typically used to manage pain, inflammation, anxiety, and on. In fact, in the case of certain epilepsy disorders, there are even times when CBD is the only thing that truly helps. None of this isn’t saying that using CBD doesn’t carry along minor side effects, which we will discuss in more detail later on.
While generally noted for its low side-effect profile, research shows CBD does have one significant side effect of note. And that is the potential for it to interact with certain prescription drugs that are metabolized by a family of enzymes. Known as Cytochrome P450, these enzymes, in particular, CYPA4, are responsible for breaking down about 60 percent of clinically prescribed medications.
While this news jumps out to many as incredibly alarming, it’s not uncommon for foods, supplements, and common medications themselves to inhibit CYP enzymes, causing drug interactions. Grapefruit, St. John’s wort, and kale can all cause drug interactions by inhibiting the same enzymes CBD products can. Then foods such as broccoli, spices like cumin, and drinks like coffee can all interact with the medication we take.
Because many of these are common items in a human’s diet, one way to quickly find out if CBD could interact with the medications you’re taking is to look on the drugs’ label for warnings about eating certain foods, in particular, grapefruit. This isn’t so easy with medications for our pets, however that’s why we are here to help. Because including CBD in our dogs and cats’ health regime is a great way to give them the health they deserve. The therapeutic effects of CBD are countless, and we will be covering the main health benefits in addition to advising you on how to safely use CBD alongside other medications.
What Happens When CBD Inhibits The Cytochrome P450 System?
By temporarily inhibiting cytochrome P450 enzymes, CBD along with the other cannabinoids found in all cannabis plants are able to delay the rate they break down their intended medication.
The metabolism rate of a drug is quite important for several reasons and must be known before an appropriate dosage can be prescribed. By delaying a drug’s metabolism rate, CBD can allow for too much medication to be in your system at once. And in essence, by raising the drug’s potency, this acts as if you took a higher dosage of that drug than normal. By effectively raising the dosage, you’re often increasing the risk for the said drug to cause side effects.
Research on the significance CBD can interact with other medications is still heavily being looked into, and discussed below. Anecdotally, we know that both marijuana and hemp products are commonly used alongside other medications. As we know, there is no great worry in the marijuana community at large about their use interacting with their prescribed medication. The same can’t be said when it comes to the side effects to memory and motor control due to the high amounts of THC found in these plants.
We can theorize from this, that while cannabis products can cause drug interactions and it is not something to take lightly, it’s not significant enough by large to cause a great concern amongst its users. It is important to note that Delta-9-tetrahydrocannabinol (THC), limited to 0.3% in CBD products vs 20%+ in marijuana is heavily involved in inhibiting CYP enzymes. Both CBD and THC are metabolized by CYP3A4 while THC is also metabolized by CYP2C9 and CBD by CYP2C19. From what we currently know, the less CYP are enzymes inhibited, the less chance it can interact with other medications. Along with its inability to cause a high, along with being available for kids and pets, this is another reason CBD oil may be the preferable choice vs medical marijuana.
However, don’t let this trick you into thinking that there isn’t good evidence that we shouldn’t be concerned about it. We have studies that show evidence of CBD itself raising the potency of blood-thinning medication along with seizure medication, causing a higher occurrence of side effects vs. the control groups.
Using CBD Safely With Other Medication
While CBD and other CBD products have the ability to interact with around 60% of prescribed medication, there are several ways to safely use CBD in conjunction with other medications.
First, never stop giving your pet medication prescribed by your veterinarian until you’ve consulted them. This goes for medication that may have a potential interaction with CBD and medication that doesn’t.
From starting CBD off at a lower dose than normal to timing out when CBD should be given to allow for the prescription drug to break down first, there are lots of little things that you can do to improve the safety of CBD. Your veterinarian can help you with these. As well, they can monitor blood plasma levels to ensure your pet’s medication is being properly metabolized or if it could do for a dosage adjustment.
There are times when CBD is touted for its ability to lower the reliance or dosage of prescription medication. One reason this happens is that CBD offers its own benefits. But the other reason we speculate this happens is that CBD may be raising the potency of the other medication in the body.
Last, even in the rare case your pet can’t ingest CBD due to a drug interaction, all hope of ever giving them CBD isn’t lost. The beneficial compounds found in CBD, and in hemp and cannabis products can be administered topically. CBD lotions, salves, and creams are great for help with surface-level aches and pain, skin breakout, inflammation, and more, These do this by avoiding entering the bloodstream, largely preventing CBD from interacting with Cytochrome p450 enzymes.
The skin is the largest organ and the first level of defense against nasties that can put severe stress on the body. Including CBD and hemp in your pet’s skincare regime is a great way to care for their general health.
Side Effects Of CBD
Without a doubt, the biggest and in most cases, the only side effect that comes from using CBD is its ability to interact with other medications. However, there are some minor side effects to be aware of. In most cases, these side effects occur when too large of a dose is given. CBD has a biphasic effect where low and common dosages can put a slight pip in your pet’s step. However, give your dog or cat too much, and you may find them catching some heavy Zzzz’s on the couch.
Another side effect of CBD, along with other cannabis products, is dry mouth. CB1 and CB2 receptors which make up the endocannabinoid system — the system cannabis largely interacts with — are found heavily in the mouth where they help regulate saliva production. But by the same token, the opposite of dry mouth can happen, and CBD may temporarily boost saliva product/release. CB1 receptors are overstimulated with high-THC products like marijuana. Because there are only trace amounts of it in CBD products, issues like dry mouth are much less commonly seen.
High doses of CBD can lower resting blood pressure causing some lightheadedness, which should quickly pass. One 2017 study found the potential for CBD to help lower blood pressure in those with high blood pressure.
Nausea and stomach discomfort are frequently cited side effects seen with nearly every medication. This especially happens when first starting a medication due to the body needing to take time to realize it’s not a threat or allergy. The same can happen with CBD, despite it usually having adverse effects and helping with nausea and stomach discomfort. Changing the dosage while the body learns to recognize CBD can help. Usually, a lower than normal dose for a few days to a week is a great course of action for this side effect.
What Research Says
Research on CBD, and cannabidiol itself, and the potential for drug interactions so far has been a bit of a mixed bag. Some researchers have found a low dose of CBD is effective enough in avoiding interactions with the drugs they were studying. While other researchers have found a precise dosage – that can be either low or high – is preferable and dependent on the patients’ and their medications. So how do we interpret this data?
First, the big thing that comes from the studies we have found is while CBD can cause interactions with the medication we take, studies still find CBD is a safe and effective treatment. With simple monitoring and potential adjustments in the dosage, there is little risk to continue using CBD. This is awesome news!
The reason a low dose usually works, but not always for avoiding a drug’s side effects is likely due to the individual cytochrome that’s responsible for the metabolism of the drug. Researchers have found CBD can both speed up and slow down the metabolism rate depending on the drug and the cytochrome it interacts with. Again, while there is some risk with CBD, when given the appropriate care, the data shows CBD is very low risk.
Clinical trials show care and safety should be given in the case of epilepsy because while CBD can significantly help seizures, they can easily interact with seizure medications increasing their side effects, which can produce seizures of their own. However, again, researchers have found CBD and seizure medications can be used together with a smart medical treatment plan. In fact, epilepsy is currently the only thing the FDA has approved the use of CBD for.
Frequently Asked Questions Concerning CBD and Drug Interactions
We hope our article has provided you with all the information you need when deciding if CBD is something you should give to your pet. Especially if they are already on medications. Because we’ve taken such an extensive look at CBD and its potential for causing a drug interaction, we wanted to quickly answer some of the most asked questions concerning the topic.
Can You Take CBD With Medication?
In the large majority of cases, CBD can safely be used with most medications. Using CBD in tandem with over-the-counter medications warrants little to no concern. If using an OTC drug long-term or at a higher than normal dosage due to medical advice from your doctor or vet, please consult said authority before using a CBD product. While a CBD product has the potential to cause drug-drug interplay in about 60% of prescription drugs, for the most part, with the proper medical advice and guidance, CBD can be safely used.
What Meds Does CBD Interact With?
CBD has been shown to interact with blood-thinning drugs like Warfarin, raising abnormal liver enzymes along with inducing tiredness when used in conjunction with Valproic Acid – sometimes used for controlling seizures. This information comes from research on Epidiolex, an FDA-approved cannabis extract for help with epilepsy. Epidiolex is an isolate, meaning it only contains the single cannabinoid, cannabidiol, in very high amounts. Most CBD products aren’t a single cannabinoid but contain the full range including high amounts of cannabidiol.
For a full list of potential drug interactions, please see our list at the end of the article.
Can CBD Interfere With Arthritis Medications?
In the large majority of cases, it’s very unlikely CBD would interfere with the metabolism of drugs used to treat arthritis and other inflammatory joint disorders. For help with pain and joint issues, veterinarians commonly prescribe nonsteroidal anti-inflammatory drugs (NSAIDs) that are safe for dogs. Except for diclofenac, it appears CBD will not have a drug-drug interaction with an NSAID drug. While NSAIDs are commonly given to dogs, the over-the-counter medications we commonly take – like Ibuprofen – should only be given to your dog under the supervision of your vet due to their ability to easily pass the safety threshold in dogs.
Does CBD Interfere With Blood Pressure Medicine?
While high blood pressure and hypertension occur in humans more, our dogs are susceptible to the disease and put on similar medications, as well. Because CBD can lower blood pressure and potentially help those with hypertension, it can seem like a good idea to use it in conjunction with drugs designed to do the same, but caution is advised. While CBD can be used in tandem with blood pressure medications, it’s recommended you discuss it with your veterinarian first.
There are several medications used to treat high blood pressure, including angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), diuretics, and calcium channel blockers. Because of this, if your vet finds they like what CBD is offering your pet, but they see it interacting with their medication, they have the option to switch to a different medication.
Has CBD Ever Caused A Life-Threatening Drug Interaction?
To the best of our knowledge and thorough research, we can not find an example of CBD or any cannabis product causing life-treating drug interactions.
Again, this should not make you disregard potential drug interactions. Instead, we are simply saying that while cannabis can cause such, it’s frequently used alongside other medications, often without the guidance of a health provider, yet for whatever reasons, a crisis has not occurred.
Discussing CBD And Drug Interactions With Your Vet
CBD has a world of therapeutic benefits that can improve our pets’ health in both small and big ways. Backed by research, CBD oil and other CBD products have been shown to be extraordinarily low-risk options for the benefits it has. However, while you can use CBD in tandem with other medications, there is a chance for an interaction that can increase the risk of the drug causing side effects. Interactions cannot happen with all drugs, but a majority of prescription medications (about 60%) have potential. This includes medication commonly used to treat epilepsy, for which CBD is commonly used to help as well.
If your dog or cat is on medication, and you’re concerned about CBD and its potential for drug interactions, your best bet for advice is their vet. While CBD may interact with medications your pet is on, your vet can safely assess if CBD is still the correct choice for them. Often timing out the dosages or changing the dose of CBD or the other medications can allow them to be used together for the best of both worlds.
With proper care, current research indicates CBD can offer a treatment plan an irreplaceable tool for improving health without causing serious adverse side effects, even when there is potential for a drug interaction.
List Of Known Drugs CBD Interacts With
If either you or your pet is on one or more of the medications listed below, please consult the appropriate medical professional before using CBD. Just because a medication is listed below does not indicate that it can never be used in conjunction with CBD or another cannabis product. Nor does it mean you will personally see drug interactions or side effects from them. Instead, it simply means there is potential for an interaction that you should be aware of.
Our aim for this list is to give a comprehensive reference point. However, there is always the chance we could have missed some medications. As well, there are studies and clinical trials dedicated to the research of CBD and drug interactions currently in operations that could change our list.