CBD benefits are widely discussed, but whether CBD for IBS is a viable treatment option is still being studied. However, here’s what early research says. CBD’s powerful anti-inflammatory effects may help people suffering from irritable bowel syndrome. Read on to learn how CBD relieves symptoms of IBS. CBD (cannabidiol) in the form of oil, gel, and capsules has been touted as the new cure-all for everything from migraines and chronic pain to seizures. But when it comes to using CBD for irritable bowel syndrome (IBS), very little is known. With up to 1 in 10 people worldwide experiencing IBS, there is growing interest to see if CBD could be a new tool to relieve symptoms.
What You Need to Know About Using CBD for IBS
The Curious Role of the Endocannabinoid System in Gut Health
With the increasing legalization of cannabis and its by-products in the United States, CBD oil — otherwise known as cannabidiol — is everywhere. You can find it in gas stations, grocery stores, as well as in specialty boutiques and cannabis dispensaries, and it’s recommended for a wide range of health concerns.
One of the things CBD is recommended for is Irritable Bowel Syndrome (IBS). Some early research suggests that CBD may be able to influence your gut inflammation, motility, and even your gut microbiome. Is CBD for IBS a valid treatment option?
Currently, there is almost no direct research suggesting that CBD can improve IBS symptoms.
Let’s explore what CBD is, what we know about the effects of CBD for IBS and the digestive system, and what we know and don’t know about how it may treat Irritable Bowel Syndrome (IBS) or other digestive conditions.
What Is CBD?
Cannabidiol (CBD) is one of many cannabinoids, which are cannabis plant compounds produced by Cannabis sativa and hemp plants. CBD is non-intoxicating and non-psychoactive. CBD’s more famous cousin, THC (tetrahydrocannabinol), is the cannabinoid responsible for the well-known psychoactive effects of smoking or consuming cannabis.
Companies that sell CBD products promote it to help remedy a wide range of health concerns, such as chronic pain [ 1
Trusted Source PubMed Go to source ], headaches, joint pain, appetite, sleep, and digestive complaints like IBS.
CBD appears to be able to act as a pain reliever and has anti-inflammatory properties several hundred times stronger than aspirin . However, there is a tendency to generalize claims about full-spectrum cannabis — extracts of whole cannabis — and CBD alone. To more fully explain, we need to dive into the specifics of the endocannabinoid system.
Endocannabinoid System 101
It may surprise you to learn that the human body creates its own cannabinoids and has a vast network of cannabinoid receptors.
This means your body is wired to benefit from cannabinoids. This endocannabinoid system (ECS) plays an important role in the development, balancing, and resilience of your central nervous system and immune system [3, 4
There are two main types of cannabinoid receptors: CB1, and CB2. CB1 receptors are concentrated primarily in your brain and peripheral nervous system, while CB2 receptors are located not only in your brain and nervous system but also in your digestive and immune systems [ 5
Trusted Source PubMed Go to source ]. CBD can bind to either type of cannabinoid receptor.
Some researchers have proposed that endocannabinoid deficiency may influence gut conditions like IBS, pain conditions, such as fibromyalgia and migraines [ 6
Trusted Source PubMed Go to source ], as well as autoimmune diseases [ 7
Trusted Source PubMed Go to source ]. Endogenous cannabinoids (meaning those produced by your body), like anandamide, are thought to influence pain perception and gut motility (the movement of waste through your digestive tract) [ 8
Trusted Source PubMed Go to source ]. For this reason, many people are excited about the potential of cannabinoids like CBD to help chronic pain, opioid addiction, and IBS symptoms like bloating, constipation, and hypersensitivity [ 9
CBD for IBS (Irritable Bowel Syndrome)
Irritable bowel syndrome (IBS) is a common digestive tract disorder. Frequent digestive systemsymptoms of IBS include [ 10
- Abdominal pain or cramping
- Diarrhea or loose stool (IBS-D), or constipation (IBS-C)
- Food sensitivities
The root causes of IBS vary widely, from bacterial overgrowth to nervous system imbalances that affect gut motility. Because of this, treating IBS requires a multi-faceted approach.
Many people with other digestive conditions — such as Inflammatory Bowel Diseases like Crohn’s disease and ulcerative colitis — also have IBS symptoms.
Does CBD Help IBS?
There is not yet clear evidence that CBD can help IBS symptoms, despite some interesting preliminary results and hopeful theories.
In the end, dietary changes such as a low FODMAP diet [ 11
Trusted Source PubMed Go to source ] have proven and documented benefits for IBS where you don’t have to wait for further research. So, while we explore the research so far about CBD and IBS, please don’t ignore more proven approaches.
Multiple literature reviews suggest that targeting the endocannabinoid system with CBD or other cannabinoids may provide some benefit for IBS patients and their symptom flare-ups, as well as patients with other gastrointestinal disorders such as inflammatory bowel disease (IBD) [ 16
However, there is little direct clinical evidence to suggest you are likely to benefit from CBD if you have IBS symptoms..
Here is a summary of the evidence that suggests CBD may be beneficial for IBS symptoms:
In a large observational study, CBD was associated with reduced gut and non-specified pain [ 19
Trusted Source PubMed Go to source ], normalize both slow and fast gut motility , and positively affect nerve channels that regulate gut motility and secretion [ 25
Out of all these studies, only two are placebo-controlled clinical trials. The rest are lower quality observational, or animal studies, which may or may not have relevance for humans, and none of them specifically studied IBS. So even though these are positive findings, they are not a clear endorsement of CBD.
Add to that the following study results, which don’t support using CBD for IBS symptoms:
A 2021 SR/MA of 15 nonrandomized studies and 5 RCTs concluded that cannabinoids do not induce clinical remission or affect inflammation in IBD patients (although there may be some improvement in symptoms) [ 27
Using CBD for IBS
CBD oil is allowed to be sold throughout the United States as long as the THC content is below 0.3%. People typically consume CBD products orally as an oil, but they can also be consumed as a tincture (a preparation of CBD in alcohol or glycerin) or edible product (like a gummy or baked good).
In states where cannabis is legal, either for medicinal or recreational use, some CBD products may contain varying levels of THC. Some evidence suggests that therapeutic results are better when CBD is given together with other cannabinoids, including THC [ 30
Trusted Source PubMed Go to source ]. This is known as the “entourage effect.” However, not everyone wants the psychoactive side effects of THC. Read your labels carefully, or request help interpreting the information on product labels.
Your ideal dosage will vary widely depending on your body’s needs, the potency of the product, and your tolerance. For best results, consult with a health care provider or medical professional who is knowledgeable about CBD dosing and your medical condition.
CBD Oil Side Effects and Safety
If you want to try CBD for IBS, keep the following considerations in mind.
CBD Side Effects
CBD is often promoted as a safer alternative to medications, but some people do experience side effects.
CBD and other cannabinoids are metabolized in the liver and intestines.
Too much CBD can damage the liver, especially if mixed with other medications, such as leflunomide, lomitapide, mipomersen, pexidartinib, teriflunomide, and valproate . If you are taking these medications or have an existing liver condition, consult a physician before using CBD.
CBD oil consumption can cause possible side effects [ 32
Trusted Source PubMed Go to source ]. These include:
- Nausea or vomiting
- Diarrhea 
- Decreased appetite
- A minority of people may have an intolerance to cannabis oil or its carrier oils such as sesame oil.
A systematic review and meta-analysis found that adverse gastrointestinal tract events may be more common when CBD and other cannabis-based medicines are ingested rather than inhaled [ 36
Non-FDA-approved CBD products on the market vary greatly in quality and consistency. This raises two potential issues:
Without independent laboratory verification, one cannot know whether the dosage of such products is accurate, if the THC content is less than 0.3%, and whether they are unadulterated and uncontaminated [ 37
Always buy CBD products from manufacturers who are transparent about their production methods, quality-control measures, and potency. Look for independent laboratory verification of product contents.
Probiotics and the Endocannabinoid System
Some very early evidence suggests that the gut microbiome may influence the endocannabinoid system [ 38
One clinical study showed that Lactobacillus probiotic supplementation increased the function of cannabinoid and opioid receptors and reduced pain [ 39
Trusted Source PubMed Go to source ]. Dogs with motility problems who were given probiotics showed an increase in cannabinoid receptor action and improved motility [ 40
Trusted Source PubMed Go to source ]. Another study, albeit in mice, suggested that CBD increased the abundance of beneficial gut bacteria but also increased the expression of inflammatory cytokines [ 41
We know that probiotics are a clinically effective treatment option for a wide range of digestive complaints [ 42
Trusted Source PubMed Go to source ]. We don’t need to know whether their interaction with the endocannabinoid system is one more reason for their benefits, but it’s an interesting line of research for the future.
The Truth About CBD for IBS
CBD may be popular, but there isn’t yet proof that it helps IBS symptoms. While early data suggest it may play a helpful role in regulating gut motility, reducing gut pain, and supporting the nervous system, much more research is needed.
There are many proven and effective treatments for IBS, and it makes sense to keep your focus on these approaches. However, If you’re CBD curious, try CBD as a short-term trial and don’t expect miracles.
CBD for IBS: Benefits, Dosage, & How to Use It?
Irritable bowel syndrome or IBS is a chronic inflammatory condition of the digestive tract. This causes stomach ache, painful abdominal cramping, constipation or diarrhea, urgent bowel movements, and bloating of the stomach. Triggers like stress, eating certain foods, and even hormonal changes make the symptoms worse.
While we lack specific studies focusing on CBD and IBS, many people find that CBD helps control their symptoms. Not only is CBD safe to take daily, but it also helps maintain a healthier gut.
In this article, we’ll discuss different ways CBD helps relieve IBS symptoms. We’ll also cover how to use CBD and get the best dosage for your IBS.
What is Irritable Bowel Syndrome?
Irritable bowel syndrome often gets confused with inflammatory bowel disease. While both conditions share many similar symptoms, irritable bowel syndrome is inflammation of the digestive tract, while inflammatory bowel disease is inflammation of the bowel walls.
The exact cause of IBS remains unknown, but a family history of IBS increases your risk of developing this chronic health problem. Several factors also worsen the condition. These include food, illness, stress, depression, anxiety, hormonal changes, etc.
Left untreated, IBS can cause extreme fatigue and tiredness, worsening mental health problems, heartburn, and indigestion.
How is Irritable Bowel Syndrome Treated?
IBS has no known cure, and no drug can fully control the disease. We only have medications that provide symptom relief. These include fiber supplements and laxatives for constipation as well as antidiarrheal medications.
Analgesics and anticholinergic drugs may also be given for painful spasms of the gut. For anxiety and depression, anxiolytics and antidepressants may be prescribed.
Change in diet also helps, so know your food triggers and avoid them. We also recommend getting enough sleep and going on a regular exercise program.
With CBD’s increasing popularity as an anti-inflammatory agent, many people add CBD to their health regimen. They find that it helps them deal with the symptoms and improve their quality of life.
How can CBD control your IBS symptoms, and how do you use CBD for IBS?
The Endocannabinoid System and Your Digestive System
The endocannabinoid system (ECS) plays an active role in your digestive system and helps regulate many of its functions . The ECS helps modulate gut motility as well as gut permeability. It also influences hunger signaling and interacts with the gut’s normal microbiota.
When there’s a noxious stimulus like an illness or consuming something toxic, the gut cells release endogenous cannabinoids (endocannabinoids) that bind to the cannabinoid receptors of other gut cells.
Activation of the type 1 cannabinoid receptor slows down peristalsis. This series of involuntary gut muscle contractions move food from the esophagus down to the small intestine. The type 1 cannabinoid receptor also reduces the secretion of gastric acid. All these allow better absorption of food.
Activation of the type 2 cannabinoid receptor, on the other hand, influences the immune cells found in the gut.
Endocannabinoids offer many therapeutic effects, but unfortunately, their effects don’t last long. They’re easily degraded by enzymes and quickly reabsorbed back into the cells.
Chronic gut problems also affect the health of your ECS, resulting in ECS dysregulation. ECS dysregulation, in turn, worsens many intestinal problems, including IBS .
How Does CBD for IBS Help Improve Symptoms?
CBD doesn’t directly activate the type 1 cannabinoid receptor but stimulates other receptors responsible for symptom control. CBD directly binds to the type 2 cannabinoid receptor found on the immune cells, activating it to produce anti-inflammatory effects.
Below are some of the beneficial effects of CBD for IBS.
CBD and Gut Pain
People suffering from IBS often complain of abdominal pain. This is sometimes triggered by food and relieved by a bowel movement. The abdominal pain may also cause painful bloating of the stomach.
CBD acts on several receptors responsible for modulating pain sensation. These include the vanilloid, glycine, serotonin, and adenosine receptors. When CBD activates these biological systems, they “tell” the cells to stop releasing pain-generating chemicals .
CBD stimulates not just the pain receptors on the gut cells but also on the brain cells.
CBD and Gut Inflammation
Inflammation serves as the body’s primary defense. Once it detects the presence of bacteria, toxins, or illness, for example, it sends immune cells to the area. The immune cells then engulf the attackers and the cellular debris they cause.
Unfortunately, the constant bombardment of noxious stimuli worsens inflammation. Inflammation gets deteriorated by the immune cells releasing chemicals that signal more immune cells to the area. All these results in chronic, low-grade inflammation of the gut, which, of course, makes IBS symptoms worse.
CBD acts as a potent anti-inflammatory agent in the gut and its inner lining. It binds to the type 2 cannabinoid receptors on the immune cells and triggers a cascade of chemical signals. This effect stops immune cells from releasing pro-inflammatory compounds and also induces the death of the abnormal immune cells .
CBD also targets other receptors that control inflammation, such as PPARy, serotonin, vanilloid, GPR55, and adenosine receptors .
Due to its remarkable anti-inflammatory properties, researchers analyzed the potential benefit of CBD in treating ulcerative colitis, Crohn’s disease, and IBS,
CBD and Gut Motility
IBS affects gut motility. The abnormal gut contractions may result in constipation, diarrhea, or a combination of the two. It also causes stomach cramping with painful bloating.
In normal situations, CBD only produces a weak inhibitory effect on gut motility. However, CBD shows a modulatory effect when gut motility is abnormal and helps normalize constipation or diarrhea gut motility.
Again, CBD produces these effects through non-cannabinoid receptors.
CBD and Anxiety and Depression
People with IBS have a high risk of developing mental health problems like anxiety and depression . While mental health problems don’t cause IBS, they can aggravate IBS symptoms since they increase the brain cell’s sensitivity to pain.
CBD produces antidepressant and anti-anxiety effects through its stimulation of the serotonin receptor . It also helps maintain the balance between the neurotransmitter levels in the brain, an imbalance of which may result in anxiety and depression.
CBD and the Endocannabinoid System
As mentioned earlier, ECS dysregulation contributes to the worsening of IBS symptoms.
Now, CBD promotes a healthier ECS. Not only does CBD stimulate the ECS, but it also allows the endocannabinoids to stay longer in the system.
Studies found that CBD actively competes with the endocannabinoids in binding to the enzymes. With more CBD attaching to the enzymes, the endocannabinoids stay longer in the body and produce more health benefits .
How to Use CBD for Irritable Bowel Syndrome
Most CBD products tell you to take a full dropper for your IBS symptoms daily, but because we’re all built differently, this dose may either be too high or too low for you. Either way, incorrect CBD dosage prevents you from enjoying the full therapeutic effects of CBD.
The rule of thumb when finding the right CBD dosage is to use:
- 1 mg of CBD per 10 pounds of body weight for low-strength dose (mild symptoms and general health)
- 3 mg of CBD per 10 pounds of body weight for medium-strength dose (moderate symptoms)
- 6 mg of CBD per 10 pounds of body weight for high-strength dose (severe symptoms)
Let’s say, for example, that you weigh 150 pounds and are experiencing severe IBS symptoms, and then you’ll need at least 90 mg of CBD.
To know how much CBD is in one full dropper, you have to divide the total milligrams of CBD by the size of the bottle.
If you bought an extra-strength CBD oil at 3000 mg of CBD in a 15 mL bottle, then divide 3000 by 15, and you’ll get 200. This means that one full dropper gives you about 200 mg of CBD. Because one full dropper contains about 20 drops, each drop gives you about 10 mg of CBD. For your severe IBS symptoms, you’ll need nine drops of CBD oil.
If you developed some adverse side effects on your first dose, reduce the amount when taking your CBD oil next. However, if you didn’t feel anything on your initial dose, we suggest staying on it for at least three to five days before increasing the dose.
Remember, our bodies respond differently to CBD. Some may feel immediate effects, while others may not, so let your body get used to CBD first before adjusting the dose.
Take notes of your body’s reaction to CBD as well. List down the CBD dose, the time you took the oil, the effects, etc. This will help you find the right CBD dose.
The best thing about the trial-and-error approach is that you’re given the freedom to find the best CBD dose that relieves your IBS symptoms.
How to Choose Your CBD Product
The CBD market offers hundreds of CBD brands, so to help you reach an informed decision, please consider these factors: types of CBD, forms of CBD, quality of the CBD products.
Types of CBD
The types of CBD include pure, broad-spectrum, and full-spectrum CBD products.
As the name implies, pure CBD only has CBD isolate. It contains no extra ingredients. Broad-spectrum and full-spectrum CBD, on the other hand, not only contain CBD but extra cannabinoids as well. They also contain essential terpenes that boost the effects of cannabinoids. What sets the two apart, though, is that full-spectrum CBD also has THC.
Hemp-derived CBD has a THC level of no more than 0.3% and is available to everyone even without a doctor’s recommendation. Marijuana-derived CBD, on the other hand, typically has a higher THC level and may only be available in states that legalized marijuana. Before buying marijuana-derived CBD, know your state’s CBD laws to avoid problems.
What’s better among the three types then?
They all help relieve IBS symptoms. However, the addition of THC in full-spectrum CBD makes it stronger and more effective in controlling symptoms. THC boosts the effects of both the cannabinoids and terpenes — it’s a phenomenon called the entourage effect.
Forms of CBD
The most common forms of CBD products include CBD oils, tinctures, edibles (gummies, candies, bars, brownies), capsules, vape oils, concentrates, flowers, and even suppositories. Suppositories deliver CBD closest to the digestive tract so that they may work best for severe IBS symptoms.
The effects of CBD edibles take some time (about 30 minutes to an hour), depending on your metabolism. CBD goes through the digestive system and liver first before entering the bloodstream.
Their effects can take less than 30 minutes for the rest of the CBD forms since CBD bypasses the digestive system and liver. The cells immediately absorb them, and CBD directly joins the bloodstream.
Edibles produce the longest duration of effects since CBD gets to stay longer in the body. On the other hand, these effects are delayed due to the first-pass metabolism in the liver.
Whatever type and form of CBD you choose, you need to use CBD religiously to enjoy its full effects.
Quality of the CBD Product
Again, the CBD market remains unregulated, so you have to know what to look for in premium-quality CBD products when you buy locally or online. These include:
- Laboratory test result or certificate of analysis by a certified third-party: This shows the CBD product’s quality, potency, and safety. It looks for the presence of toxic residues, harmful residual solvents, heavy metals, and pathogenic microbes. It also makes sure that the product contains its stated cannabinoid and terpene profiles and potency.
- CBD source: The source material must be organically grown and free from artificial pesticides. CBD should also be extracted using safe and clean methods like the supercritical CO2 extraction process.
- Customer reviews: These tell a lot about the CBD product, so stay away from those receiving more negative feedback than positive ones.
Final Thoughts — Can CBD for Irritable Bowel Syndrome Benefit You?
Irritable bowel syndrome is a chronic medical condition that can negatively affect your daily life. If left untreated, the symptoms will only worsen and prevent you from enjoying life.
CBD has many properties that may prove effective for IBS symptom management. Not only can it help control pain and inflammation but also help with gut motility and mental health problems associated with this disease.
Are you using CBD for IBS? Does it help with your symptoms? Share your experience below.
References Used in the Article:
- DiPatrizio N. V. (2016). Endocannabinoids in the Gut. Cannabis and cannabinoid research, 1(1), 67–77. https://doi.org/10.1089/can.2016.0001 
- Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. https://doi.org/10.3390/antiox9010021 
- Martínez, V., Iriondo De-Hond, A., Borrelli, F., Capasso, R., Del Castillo, M. D., & Abalo, R. (2020). Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals?. International journal of molecular sciences, 21(9), 3067. https://doi.org/10.3390/ijms21093067 
- Kabra, N., & Nadkarni, A. (2013). Prevalence of depression and anxiety in irritable bowel syndrome: A clinic-based study from India. Indian journal of psychiatry, 55(1), 77–80. https://doi.org/10.4103/0019-5545.105520 
- de Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrión, O., Crippa, J. A., Zuardi, A. W., Nardi, A. E., & Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & neurological disorders drug targets, 13(6), 953–960. https://doi.org/10.2174/1871527313666140612114838 
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
CBD for IBS: Your Questions Answered
CBD (cannabidiol) in the form of oil, gel, and capsules has been touted as the new cure-all for everything from migraines and chronic pain to seizures. But when it comes to using CBD for irritable bowel syndrome (IBS), very little is known. With up to 1 in 10 people worldwide experiencing IBS, there is growing interest to see if CBD could be a new tool to relieve symptoms.
Your CBD dictionary
There are a lot of words used in this space that sound the same, or are used interchangeably. So before we get started, let’s all get on the same page:
- Cannabis: Cannabis sativa is the plant CBD is sourced from.
- Marijuana: Another name for cannabis, more commonly used when talking about recreational use.
- Hemp: A strain of cannabis that is often used in medicine, clothing or building materials. It usually has lower levels of THC, which means it won’t produce a ‘high’.
- Medicinal cannabis/marijuana: Cannabis that is grown for the purpose of medicinal use. It usually has lower levels of THC. May also be called hemp.
- Phytocannabinoids: Compounds found in the cannabis plant.
- CBD:Cannabidiol is one of 113 phytocannabinoids found in cannabis plants. Has potential medicinal applications and does not produce a ‘high’.
- THC:Tetrahydrocannabinol is another of the phytocannabinoids found in cannabis plants. Produces a ‘high’.
What is CBD?
CBD, also known as cannabidiol, comes from marijuana, but it shouldn’t be confused as the same thing.
The marijuana plant (or cannabis) is made up of hundreds of different compounds. Over 100 of these are phytocannabinoids. CBD is one of them.
In recent years, there has been an increase in research into CBD for medical purposes as it has been shown to have anti-epileptic, anti-inflammatory, and anti-psychotic properties.
Tetrahydrocannabinol (THC) is another compound found in marijuana. This is the compound that gives the ‘high’ sensation when it’s consumed.
Unlike THC, CBD will not make you ‘high’.
How is CBD consumed?
CBD is most commonly taken in oil form, with a carrier oil like coconut or hemp seed oil. You can take it straight, by holding some drops under your tongue, or you can mix it in with food and drink. You can also take CBD as a gummy, spray, capsule, or topical rub or balm.
Can CBD help my IBS?
Cannabis has been used to help manage a number of gastrointestinal (GI) conditions such as abdominal pain, anorexia, inflammatory diarrhea, and diabetic gastroparesis. However, the psychotropic effects of THC limit its use in practice.
For this reason, CBD is more clinically useful since it provides similar benefits without the ‘high’.
CBD has shown promising results for a variety of medical conditions including chronic pain, insomnia, epilepsy, multiple sclerosis, neurodegenerative conditions such as Parkinson’s disease, and side effects of chemotherapy. It is currently being investigated as a possible treatment for IBS.
It is thought that CBD may help ‘re-calibrate’ the communication between the gut and the brain. However, more research is needed to clarify the role of CBD for IBS.