Liposomal CBD Oil

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Pet Releaf Liposome Hemp Oil 100, formerly called Liposome Hemp Oil 330, is a full spectrum hemp oil extracted from USDA-certified organic hemp (the entire plant, including seeds) using a supercritical CO2 extraction method. It can be administered directly on food without losing its efficacy. The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils? Liposomal CBD supplements manufactured by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability.

Pet Releaf Liposome Hemp Oil 100 for Small to Medium Dogs

Pet Releaf Liposome Hemp Oils are made using an innovative technology that allows CBD hemp oil to be administered directly on your dog’s food without losing its efficacy. Beyond convenient administration, it is 3x more bioavailable than Pet Releaf’s standard CBD hemp oils when administered on food, giving you 3x more usage out of a single bottle. It is intended for those dogs that need a higher potency product and require the use of food to take supplements.

Pet Releaf Liposome Hemp Oil 100, formerly called Liposome Hemp Oil 330, is a full spectrum hemp oil extracted from USDA-certified organic hemp (the entire plant, including seeds) using a supercritical CO2 extraction method. The hemp oil is mixed with sustainably sourced Wild Alaskan Red Pollock Oil.

Pet Releaf Liposomes Hemp Oil 100 is recommended for small to medium size dogs.

  • 100% USDA Certified Organic
  • Herbicide and pesticide free
  • Veterinarian formulated
  • Each dropper contains 6.7 mg of USDA-Certified Organic Full Spectrum Hemp Extract (contains 3.3mg CBD and naturally occurring terpenes and flavonoids).
  • Each bottle contains 100mg active CBD.
  • Usage is dependent on weight and condition CBD is being used for. Select Ingredients & How to Use to see how long you can expect a bottle to last.

CBD has no negative side effects, nor known toxicity level.

Made in the USA and independently tested in a third-party lab for guaranteed potency.

Note: If you live in Canada, please be aware that the Canada Border Services Agency (CBSA) will confiscate packages containing CBD products. Customs regulations vary widely from country to country and we have no way of knowing the specific laws of each country. You need to check your country’s regulations on CBD supplements before ordering this type of product.

Which Pet Releaf product should you choose?

To choose the best and most economical Pet Releaf product for your dog, you should consider your dog’s weight. The higher the potency, the less oil you have to give daily, making higher potency options more suitable for medium to large dogs.

If your dog will not take supplements unless you put them in his food or a treat, then the Pet Releaf Liposomes are a better option than the regular CBD hemp oils because they can be administered directly on meals without losing efficacy. If your dog will take supplements without food and you don’t mind administering them outside of meal times, then the regular Pet Releaf hemp oils are more cost effective.

Why is Pet Releaf Hemp Oil better than the others?

Pet Releaf is the only company that controls the entire process from seed to sale.

  • The oil is extracted from Pet Releaf’s proprietary organic hemp strain, PR-33, which was chosen specifically for companion animals to ensure they receive the most beneficial amount of terpenes, flavonoids, and cannabinoids, and which is grown at the largest USDA-certified hemp farm in the USA.
  • The oil is derived from the whole hemp plant, both the stalk and the seeds (full spectrum), so it is a complete protein containing all 20 amino acids (including the 9 essential amino acids), significant amounts of the essential fatty acids (Omega 3 and Omega 6) in the 1:4 ratio recommended by major health organizations as the magic ratio for healthy benefits, the Super Omegas (Stearidonic Acid and Gamma Linolenic Acid), anti-oxidants, B vitamins, calcium, zinc, magnesium, and many other important minerals.
  • The oil is extracted using only solvent-free, supercritical CO2 methods.
  • The oil has an undetectable level of THC at 0.1%, making it well below the national legal limit of 0.3%.
  • The oil is independently tested in a third-party lab for guaranteed potency to ensure you are getting what you pay for, and to prove that no toxic solvents or chemicals were used in the extraction process. Results are available on the Pet Releaf website for complete transparency.
  • Nothing is added to the oil except organic coconut oil which is necessary to create the proper consistency; by itself, CBD hemp oil has a consistency similar to molasses and is too thick to administer as drops.
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What is CBD?

CBD (cannabidiol) is a non-psychoactive compound found in cannabis and hemp plants that has many medicinal properties, and has shown positive results in helping treat everything from pain and inflammation to anxiety and stress, both in humans and animals. While cannabis also contains THC (tetrahydrocannabinol), the compound that gives marijuana its psychoactive properties, hemp contains extremely low concentrations of THC (the legal limit is 0.3%). By extracting CBD oil from hemp, your dog can get the beneficial CBD compound without the THC. Your dog will not get “high” from these CBD products.

How does CBD interact with the body?

CBD interacts with the body via the endocannabinoid system, or ECS. The ECS is found in all mammals, and is involved in managing a variety of biological processes including digestion, metabolism, relaxation, sleep, immune response, inflammation, and even the cognitive and memory functions. The ECS is controlled by two types of cannabinoid receptors (CB1 and CB2). These receptors interact with the cannabinoids naturally produced by the brain (endocannabinoids); however, they can also interact with plant-derived cannabinoids like CBD, which can create a variety of positive responses throughout the body.

What do people use CBD oil for?

  • Reducing anxiety, phobias, and stress
  • Managing pain
  • Reducing inflammation
  • Controlling seizures
  • Controlling nausea, vomiting, and digestive problems
  • Stimulating appetite
  • Alleviating skin problems and allergy symptoms
  • Helping dogs that are anxious or easily distracted in training to relax and focus
  • Promoting overall health and well-being

Active Ingredients per Dropper (1mL):

8.3 mg Omega-3 Fatty Acids – Sourced from Wild Alaskan Pollock Oil (contains 4.8 mg EPA and 2.4 mg DHA)

6.7 mg Full Spectrum Hemp Extract (contains 3.3 mg CBD and naturally occurring terpenes and flavonoids)

Inactive Ingredients: Acacia Gum, Astaxanthin (from microalgae (Haematococcus Pluvialis), Potassium Sorbate, Purified Water, Sunflower Lecithin, Vegetable Glycerin, Xanthan Gum.

What is Liposomal CBD? Is it Worth The Money?

The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils?

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Liposomal cannabidiol is one of the most cutting-edge advancements when it comes to CBD products.

The CBD is placed in a microscopic “packaging,” called a liposome, that increases the bioavailability.

This means more of the CBD is available for your body to use.

Learn everything you need to know about liposomal CBD, including whether it’s right for you, in this article.

Table of Contents

What Is Liposomal CBD?

Liposomal cannabidiol, or liposomal CBD, refers to any CBD placed in liposomes before being packaged and sold.

The liposomes work to keep the CBD compound intact as it moves through your body, increasing bioavailability.

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Bioavailability refers to the amount of a substance that’s able to go from the digestive tract to the blood, as well as the blood to the individual tissues.

Having a higher bioavailability makes a compound stronger and faster-acting.

What Are Liposomes?

Liposomes are microscopic “packaging,” that surrounds each individual molecule of a compound to protect it from normal bodily processes like digestion.

Liposomes are “sphere-shaped vesicles,” usually made of natural phospholipids — the molecules that make up our cell membranes — so they’re totally safe to ingest [1].

Liposomes are used for various medicines and vitamins to protect the compound from the point of ingestion all the way to absorption into the bloodstream. This doesn’t necessarily mean you’re getting 100% of the compound you’ve taken — your body almost always expels at least some of the compounds you ingest.

Note that not all medications can be liposomal. It works best with fat-soluble substances or minerals. CBD is fat-soluble and works great in liposomal form.

What Is Bioavailability?

The FDA defines bioavailability as an estimate of the fraction of the dose that is absorbed into the systemic circulation, a.k.a. the bloodstream.

Bioavailability is essentially the amount of a drug or other substance the body can actually “use.” It’s usually represented as a percentage.

The bioavailability of any substance depends on how it’s introduced to the body. Introducing a drug intravenously puts bioavailability at 100% because all of it enters the bloodstream.

When you take a substance orally or any other way, bioavailability can decrease due to the metabolic and digestive processes that are designed to break down the compounds we ingest.

Liposomes increase the bioavailability of CBD because they protect each CBD molecule from degrading during the digestion process. With the liposomal “packaging” around the compound, your body can take up more of the CBD inside rather than expelling some of it through urine or feces.

What Is The Bioavailability Of CBD?

It might shock you to learn that the bioavailability of most non-liposomal, oral CBD products is very low. CBD isn’t soluble in water, which can make it harder for your body to absorb the compound [2].

So, when you take a normal CBD gummy or tincture dose, a lot of the milligrams of CBD are filtered out during the metabolic process. This leaves the bioavailability of oral CBD at about 9% [2]. For inhaled CBD products like vapes or flowers, bioavailability is greater — around 31% after smoking CBD [3].

Regardless of whether you choose to switch to liposomal CBD, it’s good to understand the approximate bioavailability of the products you like so you can have a better idea of how many milligrams of CBD your body is actually able to use.

However, keep in mind that bioavailability refers to the amount of the drug your body has the availability to take up — not necessarily the amount that actually moves into your bloodstream.

For instance, bioavailability can theoretically exceed 100%. That doesn’t mean your body would take up more than 100% of the drug that’s there, but rather that your body is available to move more than 100% of the drug into the bloodstream.

How Liposomal CBD Increases Bioavailability

Liposomal CBD increases the bioavailability of CBD by allowing the compound to stay in your system beyond the metabolic process, giving it time to absorb into your bloodstream, as we’ve covered.

The question is, how much of a difference do those liposomes really make?

A recent study compared liposomal and non-liposomal CBD, both taken orally [4]. Forty percent of the patients who took the non-liposomal CBD had CBD in their blood one hour after ingestion. One hundred percent of the patients who took the liposomal CBD had CBD in their blood after the same period.

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While there are limited studies on the increased bioavailability of liposomal CBD, the science is already there. Liposomes have been used since the 1960s for increased efficacy of tons of drugs and vitamins, all for the same reason that it’s being used for CBD now.

Compounds that are not fat or water-soluble simply need a little help getting into the bloodstream, and liposomes accomplish that.

Is Liposomal CBD Right For Me?

Despite the obvious benefits of liposomal CBD in terms of increased bioavailability, it might not be right for everyone. Because the technology is relatively cutting-edge within the world of cannabis, liposomal CBD products can be pricey and hard to find.

It’s also true that liposomal CBD isn’t really necessary if you prefer to take very low doses.

If a 50 mg dose of CBD is equivalent to around 25 mg of liposomal CBD, but the liposomal version is three times the price, it makes more sense to just use the standard CBD oil and take twice as much.

However, if you take very high doses of CBD, the price of liposomal CBD might start to feel worth it so you can get more out of the CBD you’re purchasing.

In terms of risk or difference in experience, liposomes will not impact your CBD in any way other than bioavailability. Liposomes are completely natural and non-toxic, and they’re designed to be absorbed into your blood. The only difference you might notice is higher efficacy; no additional side effects will take place [5].

Liposomal CBD

Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects [1].

Highly effective

Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.

Science Based

Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.

Better efficacy
Non-toxic

Our liposomes are essentially non-toxic and biologically degradable.

Why Liposoma’s Liposomal CBD?

CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products [2].

Liposomal CBD

To make sure that CBD arrives in the gut in its active form, a solution is to incorporate it in liposomes, which are small, carefully designed phospholipid vesicles that form very stable dispersions in water [3]. The phospholipids constitute a bilayer structure in which the CBD molecules can be safely kept dissolved, while at the same time they act as surfactants that help present them to the intestinal epithelial cells in the most optimal manner.

What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes.

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